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10 Common Side Effects and Risks of IVF You Should Know

What is IVF?

IVF (In Vitro Fertilization) has been defined as a fertility treatment where eggs are fertilized by sperm in a laboratory dish outside the body (in vitro) and the resulting embryo is then transferred to the uterus for potential pregnancy.

IVF has gained popularity. BBC reported that over 10 million children are born worldwide via IVF.

Are there risks and side effects associated with IVF? 

Yes. Consider the following 11 side effects and risks of IVF.


In a study on the impact of infertility treatment on mood, MGH Center for Women's Mental Health says: "Women with higher neuroticism scores at baseline were more likely to experience both more distress and more pronounced mood fluctuations." 

Reproductive Medicine and Infertility Association also says: "Sometimes, mood swings are to be expected, especially if a woman is undergoing hormone stimulation to boost the viable number of eggs."

thebridgeclinic.com states: "Hormonal shifts during IVF can affect neurotransmitters in the brain, leading to mood swings, irritability, or emotional ups and downs."


IVF raises injection site issues because it involves frequent injections of hormones. WIN Fertlity states: "The drugs used for ovarian stimulation have mild effects for some women, including mild bruising and soreness at the injection site." Gynoveda says: "Signs of IVF reaction may include itching, rashes, and swelling in the injection site."


Cofertility states: "Some common risks association with anesthesia include allergic reactions, breathing problems, and blood pressure changes. Springer Nature Link makes the point: "The use of general anesthesia, especially oxide, . . .has an adverse effect on IVF outcome." Society for Obstetric Anesthesia states: "Many anesthetic drugs have been detected in the oocyte follicular fluid and may potentially interfere with oocyte fertilization." Barcelona IVF states: "It is important to take into account the uncommon side effects of sedation anesthesia, which include dizziness, tiredness, discomfort, etc.


According to Mayo Clinic on IVF, the needle could cause bleeding, infection or damage to the bowel, bladder or a blood vessel. Pacific Fertility Center of Los Angeles says: "This bleeding is oftened caused by a blood vessel puncture (a needle hitting the vaginal wall during egg collection)." Nova IVF Fertility Clinic explains: "The needle used for egg retrieval can cause bleeding or infection."


According to Mayo Clinic, IVF is linked with higher risk of a baby being born with heart issues, etc. Liv Hospital points out: "Hypertensive disorders are common in IVF pregnancies. These disorders can range from mild hypertension to severe preeclampsia."

6. Ovarian hyperstimulation syndrome

Cleveland Clinic explains: "Ovarian hyperstimulation syndrome (OHSS) is a complication of IVF treatment. It causes your ovaries to swell and leak fluid into your abdomen." Mayo Clinic makes the point: "Ovarian hyperstimulation syndrome is an exaggerated response to excess hormones. It usually occurs in women taking injectable hormone medications."

Pacific Fertility Center Los Angeles says: "OHSS is a risk that affects women undergoing IVF and is the body's response to excessive or imbalanced hormone levels." MedlinePlus says: "OHSS affects 3 percent to 6 percent of women who go through in vitro fertilization (IVF).

7. Multiple pregnancy

The Fertility Institute of New Orleans states: "The number of embryos transferred during an IVF cycle directly influences the risk of twins or multiples." CCRM Fertility explains: "IVF can increase the likelihood of twins and multiples when multiple embryos are transferred." The National Institutes of Health (NIH) makes the point: "The risk of multiple births associated with IVF is directly related to the number of embryos transferred in each cycle."

8. Ectopic pregnancy

The Ectopic Pregnancy Trust on reasons why an ectopic pregnancy can occur during IVF, states: "There is a chance of ectopic pregnancy resulting from embryo transfer during IVF treatment as embryos can travel into the fallopian tube." CNY Fertility explains: "IVF carries certain risks and complexities, one of which is ectopic pregnancy, when embryo implants outside of the uterus." ABC IVF points out interesting: "Patients undergoing IVF often have conditions that predispose them to ectopic pregnancy, such as fallopian tube damage or endometriosis."

9. Miscarriage

According to felicityivf.com, chromosomal abnormalities are said to cause most miscarriages by IVF and naturally happen in early embryonic growth. Oasis Fertility ssys that IVF miscarriage could be caused by genetic defects, hormone imbalances, or uterine problems. Vardaan Medical Center says that the quality of the embryo transferred during IVF can impact the risk of miscarriage.

10. Ovarian torsion

IVF is said to cause ovarian torsion through ovarian enlargement and increased mobility from hormonal stimulation. This makes the ovaries prone to twisting around their ligaments, cutting off blood supply, especially when large cysts or pregnancy are present, often occurring after egg retrieval or in early pregnancy.

However, Cofertility explains: "Thankfully, ovarian torsion is rare during egg freezing or IVF cycles, but it does occur infrequently." The National Institutes of Health also points out: "Torsion of a stimulated ovary occurring after in vitro fertilization (IVF) intrauterine insemination is a rare event."

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