The Ultimate Guide to Sauna, Cold Plunges, and Metabolic Health

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Photo: Unsplash.com/Huum Medical Disclaimer : This is for informational purposes only. For medical advice, diagnosis and treatment, please your doctor. Metabolic health dictates your daily energy, brain clarity, and long-term health span. Today, poor metabolic fitness drives chronic fatigue, weight gain, and modern diseases. Many people look for shortcut supplements to fix their bodies. However, two ancient physical stressors offer a powerful alternative: deliberate heat and deliberate cold exposure. Read more about metabolic health. Combining saunas and cold plunges creates a unique physical challenge. This practice is often called contrast therapy. It does more than burn calories or test mental grit. It changes your cellular physiology, stabilizes blood sugar, and upgrades mitochondrial function. This comprehensive guide breaks down how thermal shock alters your metabolism. You will learn how saunas and cold water impact glucose spikes, insulin sensitivity, and metabolic rate. Part...
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FDA Approves Cablivi Injection To Treat Rare Blood Disorder in Pediatric Patients

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 This action marks first drug approved for pediatric patients with acquired thrombotic thrombocytopenic purpura.


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The U.S. Food and Drug Administration (FDA), has approved Cablivi (caplacizumab - yhdp) for injection to treat pediatric patients 12 years and older with acquired thrombotic thrombocytopenic purpura (aTTP) in connection with plasma exchange and immunosuppressive therapy.

Cablivi was originally approved in 2019 to treat adults with this condition.

Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare disorder that is even more uncommon in children, only occurring in about 1 to 10 million annually, said FDA.

aTTP causes blood clots in the small vessels. These clots can slow or block the flow of blood to parts of the heart, brain, kidneys, and other organs. In this disorder, platelets (blood cells involved in clotting) clump together, leaving fewer platelets in the rest of the body to help with clotting. In addition, red blood cells may break apart, causing anemia.


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The FDA affirmed that the efficacy of Cablivi to treat pediatric patients with aTTP was evaluated in a reproductive chart review study of 30 patients ranging from 2-8 years old. Results showed that 80 percent of patients achieved clinical remission, defined as achieving a normal platelet count and having LDH levels (a marker of red blood cell breakdown) less than 1.5 times the upper limit of normal for 30 days or more.

Because Cablivi works by targeting the abnormal blood clotting, it can also cause serious and fatal bleeding. The risk of bleeding is higher in patients with underlying coagulopathies (impaired clotting abilities) or who are also taking blood thinning medicines (antiplatelet agents or anticoagulants).

Patients should stop treatment if clinically significant bleeding occurs. Patients should also not take Cablivi 7 days before elective surgery, dental procedures or other invasive procedures. In addition, patients should not take Cablivi if they have had a severe allergic reaction to any of its ingredients.

The most common side effects are nose bleeds, headache, and gingival (gum) bleeding.

Cablivi received Orphan Drug Designation for this indication.

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